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Graduate Institute of Applied Science and Technology, NTUST
Applied and Theoretical Chemistry Group

Applied and Theoretical Chemistry Group

The direction of research programs currently are in three focused themes, as detailed in the following:

l Materials Chemistry and Nanoscience

There are four research projects in this category: (1) Organic field effect transistors, devices and materials, including the molecular design, crystal engineering, thin film morphology and molecular orientation controls on substrates, with a goal to increase the charge mobility and field effect mobility in organic thin films. (2) Light-harvesting and solar energy conversion, which develop organic, inorganic and hybrid materials that are capable of electron and energy transfer, with a goal of developing solar energy conversion devices. (3) Construction of functional organic molecules, in which molecular spacers that tether electron or energy donor and acceptors are designed and synthesized, with goals of developing molecular electronic devices and understanding the fundamental energy and electron transfer mechanisms. (4) Self-assembly nanometer-scaled structures: to design molecular shapes or functional groups, and to fabricate nano-meter scaled structured materials with specific sizes or shapes. By controlling over the density or reactivity of functional groups at the surface, we plan to offer a platform for future biomedical or optoelectronic applications.

l Catalysis

The development and application of catalysts are highly correlated with the chemical industry and the study of catalysis has been an important direction of the Institute. Emphasis in the future includes (1) The development of fuel cells. Inspired by biological systems, we plan to design a system that reduces carbon dioxide to produce methane using light, and then use enzyme derived model systems to convert methane to methanol, which is then oxidized to produce electric energy. (2) The development and application of nano-meter scaled catalysts, where properties are often distinctly different from that of other scales, this may bring a new application. Teams in the Institute have been developing silicon oxide composite materials, and studying their catalytic efficiencies in nitration and polymerization reactions. Metal and titian oxide catalysts on porous materials are also under an intense study. Answering the call for green chemistry, we have also been developing novel ionic liquids for future reaction solvent.

l Chemical Biology

In recent years, the Institute of Chemistry has been developing researches in the area of chemical biology with very good progresses. In the future, we will focus on: (1) Structure of biological molecules. We will continue on the study of protein folding dynamics and mechanism. With spectroscopic information we plan to study the orientation and structure in the Particulate Methane Monooxygenase in its membrane, in order to understand the tertiary structure inside the membrane. Cryo electron microscopy will also be used to obtain protein structures in atomic resolutions. We have also studied the formation of triple stranded DNA, which is potentially able to alter gene expression or functions, for the future application in medicine or biotechnologies. (2) Developing new glycolipid derivatives for anti-cancer and antibiotics drug developments, which is a multidisciplinary project that requires expertise from areas of synthetic chemistry, structural biology, bioanalytical chemistry, proteomics and immunology. (3) Studying the virus infection mechanisms; developing antiviral and anticancer vaccines, new inhibitors and antibodies for HIV and SARS coronavirus; developing carbohydrate-encapsulated nanoparticles as a rapid target protein identification technique.